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#qudsiaali #weightloss #weightlossjourney #ketodiet #homemadehairoilforhairgrowth #hairgrowth #drummeraheel #madehanaqvi #aroosasid #subhkasamaa #samaatv Easy Weight Loss Tips By Dr Umme Raheel | Keto Diet & Intermittent Fasting | Madeha Naqvi | SAMAA TV Homemade Hair Re Growth Tonic For Faster Hair Growth & Dandruff | Hair Growth Oli Remedy By Dr. Umme Raheel SAMAA TV is the top Pakistani news channel covering national news from a diverse array of fields -- from politics and current affairs, business and sports to international, entertainment and culture. The channel aims at providing factual, in-depth and latest news as and when it happens. Tune in to SAMAA TV to stay updated, whether at home or on the go, on all things current and relevant. ➽ Subscribe to Samaa News ➽ https://bit.ly/2Wh8Sp8 ➽ Watch Samaa News Live ➽ https://bit.ly/3oUSwAP Stay up-to-date on the major news making headlines across Pakistan on SAMAA TV’s top-of-the-hour segment. For in-depth coverage watch the bulletins. SAMAA TV is Pakistan’s first private satellite news channel that provides live transmission simultaneously from five cities of Pakistan: Karachi, Lahore, Islamabad, Quetta and Peshawar. SAMAA’s live news bulletins, incisive political talk shows and a wide range of programs including sports, social issues and infotainment has enabled it to position itself among the top tier news and current affairs channels of Pakistan. SAMAA Network : SUBSCRIBE to get the latest SAMAA News content: https://bit.ly/2Wh8Sp8 ► SAMAA News YouTube Channel: https://bit.ly/2Wh8Sp8 ► SAMAA Originals YouTube Channel: https://bit.ly/32c1qO3 ► SAMAA MONEY YouTube channel: https://bit.ly/2EkiglJ ► SAMAA SPORTS YouTube channel: https://bit.ly/34jyINP ► SAMAA ISLAMIC YouTube channel: https://bit.ly/2LT1WMF Keep watching SAMAA! For latest Urdu News updates visit: http://www.samaa.tv http://www.facebook.com/samaatvnews http://www.twitter.com/samaatv http://www.instagram.com/samaatv https://whatsapp.com/channel/0029Va8EglPLCoX1JQRteR1x Punjab Govt | CM Punjab | Punjab Assembly | Bilawal Bhutto | Imran Khan | News | Breaking News | Latest News | News Headlines | Prime Time Headlines | Samaa News | News Channel | Live News | Breaking News | Latest News | Pakistan Breaking News | Breaking News Today | News Headlines | Headlines News | Pakistan News | Headlines | Live News | News Updates | Samaa news live | Samaa | Samaa Live | Samaa News Live Streaming | Samaa Youtube Channel | Samaa Channel | Samaa Tv Live | Samaa Tv | Samaa Live Tv | Samaa Live News

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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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FAT LOSS NOW! http://howgainmuscle.org/go/fatlossnow There are no magic bullets for weight loss, but there may be a magic spice that can help you lose fat; turmeric. That's right that innocuous little bottle hiding in your spice rack might hold the secret to unlocking the mysteries of the midsection. Turmeric is nothing new. In fact it has been around for thousands of years, used in all sorts of remedies for everything from cuts and scrapes to digestion problems. It's best known as one of the key ingredients in many Indian dishes that help account for their spicy aroma and tantalizing taste. Turmeric Gets Some Respect as a Weight Loss Aid What is new is that the spice is getting some attention from serious medical researchers at prestigious institutions such as Columbia University in New York. In one recent study, Columbia researchers discovered that mice which consumed quantities of turmeric had reduced incidence of diabetes, weren't as prone to weight gain, and even had fewer liver problems than the control group. The research results were so promising that they were presented to a yearly gathering of top level scientists and doctors at the Endocrine Society. One of the primary goals of endocrinologists is to understand diseases such as diabetes, obesity, and other maladies connected to glands and hormones. The fact that the research was promising enough to warrant presentation to them speaks volumes about the efficacy of turmeric when used in weight control therapy. Why does Turmeric work to help control weight and even fight inflammation? Scientists aren't 100% sure yet, but research suggests that it is probably due at least in part to a strong antioxidant; the polyphenol curcumin. This strong antioxidant has been demonstrated to help Type 2 diabetics lower insulin resistance and lose the weight that can contribute to their disease. Turmeric is rich in curcumin. Even More Evidence of Turmeric's Effectiveness Another study demonstrating the promise held by the spice was conducted at Tuft's University. It was published in the Journal Science Daily in early 2009. This new study reveals stronger evidence that it is fact the curcumin found in turmeric that is the key compound responsible for the weight control. The study looked at not the spice, but the curcumin extracts and discovered that these extracts have a positive effect on laboratory mice losing fat. Their findings conclude that one possible mechanism for the observed weight loss is that the curcumin actually restricts the blood supply to fat cells, halting them from excessive growth. Of course, the jury is still out until more tests can be completed, but it appears the turmeric, a simple grocery store spice can definitely help you to lose fat and lower your chance of contracting weight related illnesses, not to mention look a heck of a lot better. There are several other foods that can have powerful effects on your fat loss efforts, now they have company. Check out what real users have to say about: http://howgainmuscle.org/go/fatlossnow

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Courtesy of http://www.shakerday.com/ As the time goes by, new discoveries and scientific studies about health and particularly about how to lose that undesired fat around our face and neck come out. However, as a person who has fought against fat in that precise zone, I only can recommend these exercises that were recommended more than 50 years ago. Amazing, isn't it? Try them out and let me know the results. I am sure I will hear from you in the near future. Reach out to me at http://www.shakerday.com/

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