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Week 16 Mounjaro Update Highest Weight: 13st 6/188lbs MJ Starting Weight: 13st/182lbs CW: 10st3/143lbs Timestamps: 00:00 intro 01:37 blood results 02:47 current BMI 03:18 graph showing weight loss 04:29 - NSV 05:45 - why am i so tired 07:32 - my stairmaster challenge 12:02 - my next fitness challenges 16:15 - what is my goal weight? 16:58 - pics from my previous weight loss 19:57 - intentions for this week #mounjaro #gym #weightloss #weightlosetransformation #weightlossjourney #ozempic #gymmotivation #gymlife #gymlover #plussize #zepbound #fatloss
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Please help us help Skunk - she has a bad case of #stomatitis and needs surgery right away. The only problem is that she was abandoned with more than 40 other cats, and we rely on donations to feed and care for all 44 of them. We can't save her without your help. Skunk also isn't alone. There are 5 cats here that are sick. 3 of them, skunk included, still need funding. What is Stomatitis anyway? It's a mysterious inflammatory disorder of the mouth that causes excessive swelling of the gums and throat, drooling, matted fur, severe pain, and finally, complete loss of appetite that takes them to the rainbow bridge. The treatment is extracting some of, if not all of their teeth, and it needs to be done as soon as possible. Please help us save Skunks life. She's already been through so much and she deserves a second chance at life. Links to help: ✅ Our site: https://sunshinepinesrescue.org/ ✅ Cashapp: $sunshinepinesrescue ✅ Venmo: sunshinepinesrescue ✅ #Gofundme: https://gofund.me/9d432e86 #cattok #cats #lovecats #catcolony #catsanctuary #rescuedcats #abandonedcats #sickcats #tuxedocatsoftiktok #tuxedocats #blackandwhitecats #helpcats #feedacat #helpacat #helpacatinneed #sunshinepines #coicommunity #saveskunk #felinestomatitis #stomatitis #sunshinesmiles #saveacat
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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]
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Watch: https://youtu.be/SqnylX1dGbM Subscribe: https://www.youtube.com/channel/UC4w20dXVKYd9A81PTNkyzXQ Join The IVF Class: https://the-egg-whisperer-school.teachable.com/p/the-ivf-class/ 💙 Peptides, probiotics, and adaptogens for fertility 💙 Today, I’m talking about the science behind these fertility-boosting powerhouses with nutrition expert Ayla Barmmer @aylabarmmer_rd on the latest episode of The Egg Whisperer Show podcast. 💙What Are Peptides & Why Do They Matter for Fertility? Peptides are short chains of amino acids that act as messengers in the body. Some peptides, like CoQ10 and glutathione, support egg and sperm quality by reducing oxidative stress and enhancing mitochondrial function, key for healthy embryo development. 💙Probiotics & the Reproductive Microbiome A healthy gut microbiome influences hormone metabolism and immune function, which both play a role in fertility. Specific probiotic strains like Lactobacillus rhamnosus and Lactobacillus reuteri also help maintain a balanced vaginal microbiome, which can support conception and lower the risk of miscarriage. 💙Adaptogens & Hormonal Balance Adaptogens like ashwagandha, rhodiola, and maca may help regulate the body’s stress response. Chronic stress can disrupt ovulation and hormone production. These botanicals may help reduce cortisol levels, improve sleep, and support more balanced cycles. Get Dr. Aimee's Fertility Essentials: https://www.draimee.org/fertility-essentials Subscribe to the newsletter to get updates: https://draimee.org/blog Check out the podcast: https://draimee.org/the-egg-whisperer-show-podcast Join the TUSHY Method Class: https://the-egg-whisperer-school.teachable.com/p/the-tushy-method Join Egg Freezing Class: https://the-egg-whisperer-school.teachable.com/p/egg-freezing-party/ Buy Your Fertility Pants: https://egg-whisperer.myshopify.com/ Dr. Aimee Eyvazzadeh is one of America’s most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.
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Lizzo reveals the secrets behind her dramatic weight loss journey, including switching from a vegan diet to animal-based protein. Learn how this change boosted her energy, mental clarity, and helped her shed 60 pounds. Watch to discover Lizzo's transformation and her path to health and well-being.
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