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Arecor Therapeutics PLC (AIM:AREC) CEO Sarah Howell joined Proactive's Stephen Gunnion with details of a collaboration with TRX Biosciences to develop an oral GLP-1 product for treating type 2 diabetes and obesity. GLP-1s are therapeutic peptides known for improving blood sugar levels and promoting weight loss. The market for GLP-1 products is expected to reach $100 billion by 2030. Currently, GLP-1 treatment options are predominantly injectable, which limits patient compliance and adoption. Arecor aims to develop an oral GLP-1 with enhanced bioavailability, making it a once-daily pill. This development could significantly increase access to effective treatments for these conditions. Howell told Proactive that Arecor is well-positioned for this development due to its successful track record with its Arestat technology platform, which enhances the profiles of existing therapeutics. The collaboration aims to overcome challenges faced by the only available oral GLP-1, such as low bioavailability and the need for dosing on an empty stomach, by leveraging Arecor's technology in conjunction with TRX Biosciences' Lipper core technology. She said the collaboration complements Arecor's existing diabetes portfolio, which includes two leading insulin products and Gluco, a product for severe hypoglycemia in diabetes patients. The focus is on reducing the daily burden of disease management and improving patient outcomes. TRX Biosciences was chosen for their complementary technology and expertise in oral peptide delivery. The initial development phase will last up to 18 months, aiming to demonstrate the feasibility of a stable, orally delivered GLP-1 with improved bioavailability. #ArecorTherapeutics #TRXBiosciences #DiabetesTreatment #ObesityManagement #GLP1 #OralPeptideDelivery #Bioavailability #TherapeuticPeptides #HealthcareInnovation #PharmaceuticalResearch #ProactiveInvestors #invest #investing #investment #investor #stockmarket #stocks #stock #stockmarketnews

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Kendra Wilkinson, the former reality TV star known for her candid personality and vibrant screen presence, recently opened up about her experience with a popular weight loss drug—and why she quit after just one dose. Her honest revelation is creating waves across the internet, especially as celebrity weight loss trends continue to dominate headlines. During a candid interview, Kendra revealed that she had been feeling pressured by societal standards and the constant spotlight on her appearance, which led her to try a trending weight loss medication that has gained popularity among several celebrities. However, her experience was far from what she expected. Within hours of taking the first dose, Kendra experienced physical discomfort and an emotional reaction that made her reconsider the entire process. She emphasized the importance of listening to her body and prioritizing mental well-being over rapid results. Kendra’s decision to be transparent about her journey is earning her praise from fans and health advocates alike. In an industry where quick fixes are often glamorized, her story serves as a reminder that not every trend is suited for everyone. She admitted that her desire to be "the best version of herself" should never come at the cost of her health. Instead of chasing shortcuts, Kendra now focuses on holistic wellness, including balanced nutrition, fitness, and therapy. This revelation is not just another celebrity confession—it’s a wake-up call for many who blindly follow influencer trends without understanding the possible side effects. Kendra hopes her story empowers others to research thoroughly, consult professionals, and make decisions that support long-term well-being instead of short-lived transformations. As fans continue to show support, many are praising her courage for sharing such a personal decision in the face of public scrutiny. The conversation around celebrity fitness, body image, and the pressures of fame continues to evolve—thanks to honest moments like this. Stay tuned for more updates on celebrity health journeys, wellness trends, and raw moments from stars who choose honesty over hype. Subscribe to our channel for daily updates and don’t forget to hit the notification bell for the latest buzz in the world of entertainment and lifestyle! #KendraWilkinson #WeightLossJourney #CelebrityWellness #MentalHealthMatters #WeightLossDrugs #CelebrityNews #HealthOverHype #KendraUpdate #BodyPositivity #FitnessMotivation

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We are excited to share that we’ve decided to publish our Academy's 475th chapter on YouTube for free access to all! 🎉 This is a great opportunity for everyone to check out the type of high-quality, clinically relevant content we produce for our membership students inside the Academy Membership. Are you prescribing antipsychotics and concerned about weight gain in your patients? Watch this discussion, where Dr. Harvinder Singh has summarized this clinically relevant topic in the following key discussion points (with timestamps): ✅ 03:30 Introduction: Weighing Risks & Benefits of Antipsychotics use ✅ 10:52 Should Metformin be Used for the Prevention of AIWG? ✅ 15:28 What Predictors & Parameters can Inform the Decision of When to Intervene? ✅ 27:15: At what threshold will you consider adding Metformin? ✅ 30:06 What Dose of Metformin Should be Used for AIWG Prevention? ✅ 32:00 What Monitoring is Recommended with Metformin Treatment? ✅ 34:20 Understanding Metformin’s Adverse Events ✅ 35:24 When Should Metformin be AVOIDED & STOPPED? ✅ 37:30 When are GLP-1 Agonists Indicated? Read our detailed blog post here: https://psychiatryeducationforum.com/metformin-aiwg 🔔 Don’t forget to like, subscribe, and share for more updates on cutting-edge psychiatry treatments! SUBSCRIBE ‪@PsychiatryEducationForum‬ Dr. Harvinder Singh, a dedicated psychiatry expert and creator of the Psychiatry Education Forum Academy, shares valuable clinical insights to empower busy healthcare professionals with practical psychiatry knowledge. Website: https://psychiatryeducationforum.com Instagram: https://www.instagram.com/psych_edu_forum/ Facebook: https://www.facebook.com/PsychiatryEducationForum

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We hear all about this all the time, but is it really true? Does wimpy old vitamin D NEED Vitamin K? http://www.ThomasDeLauer.com Do you need vitamin k with vitamin d? Vitamin D A hormone, not an actual vitamin, that your skin makes when exposed to sunlight, so it does not need to acquire it from food if adequate sunlight is available The only natural foods that contain vitamin D are fish and egg yolks Most of us are deficient in vitamin D as we do not spend much time outdoors. Additionally, where we live can limit our access to vitamin D - if you live below 37 degrees south or above 37 degrees north you do not have access to sufficient sunlight except during the summer months. ( This line of latitude crosses below Colorado, Utah and Kansas, so the majority of us in the US require additional dietary vitamin D throughout the year even if we spend time outdoors Sunscreen and skin pigmentation can also act as barriers to vitamin D absorption What Does Vitamin D Do? Reduces belly fat Of all the places to lose fat, the middle of our bodies is usually the hardest and the most important, both for looking lean and for being healthy. Waist-to-hip ratio is a factor in your risk for heart disease and type 2 diabetes Research bomb: A study published in the journal of Clinical Nutrition had 23 overweight participants who all went through a 12-week resistance training program. Half of them took 4,000 IU’s of vitamin D while the others received a placebo. While both groups lost the same amount of fat, the group that took the vitamin D supplements were more likely to have lowered their waist-to-hip ratio to a greater extent when compared to the placebo group. (3) Hormone Regulation and Bone Health The parathyroid glands, located in your neck, release parathyroid hormone. Parathyroid hormone regulates the calcium in your body: When the level of calcium in your blood is low, your parathyroid releases PTH. PTH signals for calcium to be leeched from bones and released into the blood, while also telling your kidneys to create more bioavailable vitamin D. This form of active vitamin D tells your gut to absorb more calcium, as long as you have sufficient vitamin D available. When you are deficient in vitamin D, your body will not absorb enough calcium from your diet and too much calcium will be taken from the bones to be available in the blood. Calcium plays more roles than just bone health - it is crucial for proper functioning of your nervous and muscular systems, so the body is able to take calcium from the bones to perform other functions. Vitamin K Vitamin K is helpful in blood clotting and bone strength. May also help to prevent heart disease, prostate cancer and Alzheimer’s Vitamin K2 and vitamin D3 work together to strengthen bones through their impact on calcium While vitamin D3 essentially regulates how much calcium is absorbed in the diet, vitamin K2 tells the calcium where to go, directing it to bones rather than soft tissues. When calcium attaches to arteries, known as hardening of the arteries, it can lead to cardiovascular complications. Without vitamin K2, the calcium absorbed will not go towards strengthening your bones, and thus vitamin K2 is crucial in the functioning of vitamin D3. Vitamin K2 comes from meats, eggs, hard cheeses and insects. Many people are also deficient in vitamin K2. Diet and Supplementation The best way to stay healthy is to eat a balanced diet full of leafy greens, fruits, veggies and lean proteins. This is how we can be sure we are obtaining a full range of vitamins and minerals. Vitamin D3 is one vitamin/hormone that we often have to supplement. If your supplement vitamin D3, be sure to obtain enough vitamin K2, either through a diet with meats and eggs, or through supplementation as well. Also be sure to obtain calcium through your diet, such as yogurt, leafy greens and legumes, or through supplementation. If you do not have all three in your diet, you may be doing more harm than good. References: 1. Parathyroid glands and vitamin D https://www.vitamindcouncil.org/further-topics/parathyroid-glands-and-vitamin-d/ 2. Vitamin D and other vitamins and minerals https://www.vitamindcouncil.org/about-vitamin-d/vitamin-d-and-other-vitamins-and-minerals/ 3. Vitamin K - the missing nutrient to blame… http://articles.mercola.com/sites/articles/archive/2011/03/26/the-delicate-dance-between-vitamins-d-and-k.aspx 4. The Vitamin D article we did https://docs.google.com/document/d/15jdoe1CI0Ao4OHKq06UYTPVMrRo5lScDZlg1fFo-rWQ/edit?usp=sharing

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පර්යේෂණවලින් පෙනී යන්නේ ඉන්සියුලින් ලබා ගැනීම ආරම්භ කරන පුද්ගලයින් පළමු වසර තුළ බොහෝ විට බර වැඩි වන බවයි. සාමාන්‍ය බර වැඩිවීම රාත්තල් 4 ක් පමණ වන නමුත් සමහර පුද්ගලයින් රාත්තල් 11 ක් හෝ ඊට වැඩි විය හැකිය [1]. මෙය සිදු වන්නේ ඉන්සියුලින් ඔබේ රුධිරයේ 00:00 අධික සීනි ප්‍රමාණයක් ඇති විට මේදය ලෙස සීනි ගබඩා කිරීම ශරීරය කරන බැවිනි. 01:00 සමහර රුධිර පීඩන ඖෂධ සීනි වැඩි කළ හැක. 03:00 බර වැඩි වන විට දියවැඩියාවද වැඩි වේ. 04:30 ඉන්සියුලින් අක්මාවේ මේද තැන්පත් වීමට හේතු වේද? 05:00 නව ඖෂධ රාශියක් තිබේ. 06:00 sglt2 ඖෂධ ගැන ඔබේ වෛද්‍යවරයාගෙන් විමසන්න. 0820 ඉන්සියුලින් කුසගින්න වැඩි කරයි. 13:00 රුධිරයේ සීනි මට්ටම ඉතා පහත වැටීම වළක්වා ගැනීම සඳහා ඔබ වැඩිපුර ආහාර ගන්නවා. 17:40 ඔයාට සල්ලි තියෙනවා නම් මේ බෙහෙත ඔයාට උදව් වෙයි. 20:00 සීමිත දීමනාව: ආහාර ගැනීමෙන් පසු රුධිරයේ සීනි මට්ටම සඳහා කරන වියදම් සඳහා මුදල් ආපසු ගෙවීම. ඔබ 2 වර්ගයේ නම්, බර වැඩිවීමට හේතු නොවන තවත් බොහෝ ඖෂධ තිබේ. ඒවාට ප්‍රධාන වශයෙන් SGLT2 නිෂේධක ඖෂධ, DPP4 ඖෂධ සහ පැරණි විශ්වාසවන්ත මෙට්ෆෝමින් ඇතුළත් වේ. SGLT2 ඖෂධවලට වකුගඩු සහ හදවත ආරක්ෂා කිරීමේ අමතර ප්‍රතිලාභ ඇත. වඩාත් සවිස්තරාත්මක වීඩියෝවක් සඳහා ඉහත සබැඳියේ වීඩියෝව බලන්න. ඔබ 1 වර්ගයේ නම්, ඔබට ඉන්සියුලින් අවශ්‍ය වේ, නමුත් රනිල කුලයට අයත් බෝංචි සහ කොළ පැහැති එළවළු මත පදනම් වූ ආහාර වේලක් අනුභව කිරීමෙන් ඔබට අවශ්‍යතාවය අවම කර ගත හැකිය. ඔබ ඉන්සියුලින් ගන්නා විට, ඔබේ ශරීරය මුත්රා හරහා කැලරි නැතිවීම නතර කරයි. මෙයින් අදහස් කරන්නේ ඔබ ඔබේ ශරීරයේ වැඩිපුර කැලරි තබා ගන්නා බවයි, එය බර වැඩිවීමට හේතු විය හැක. එසේම, ඉන්සියුලින් ඔබට බඩගිනි දැනිය හැකි බැවින් ඔබට වැඩිපුර ආහාර අනුභව කළ හැකිය. SGLT-2 Inhibitors or sodium-glucose cotransporter 2 inhibitors like canagliflozin, ertugliflozin, dapagliflozin, and empagliflozin may lead to weight loss and improved blood sugar control in people with type 2 diabetes. We will go into each one of them in detail later in this video. They are approved by most governments including the Therapeutic Goods Administration or TGA in Australia, FDA in America and The Central Drugs Standard Control Organisation (CDSCO) in India. Some of the common Diabetic medications cause weight gain. They include Insulin, Sulfonylureas like glipizide, gliclazide, tolbutamide, Metiglinides like repaglinide and Thiazolidinediones like pioglitazone. Metformin is a common medication used to manage type 2 diabetes. While it wasn’t specifically designed as a weight loss drug, some studies have found a link between metformin and weight loss. Here’s what you need to know: How Metformin Works: Metformin primarily lowers blood sugar levels by reducing the amount of glucose released by the liver. It also improves insulin sensitivity, allowing muscles to use glucose more efficiently. Lower insulin levels can lead to better overall health and reduced risk of complications associated with high blood sugar. Metformin and Weight Loss: The relationship between metformin and weight loss is not fully understood, but several theories exist: Reduced Hunger Cues: Some studies suggest that metformin may affect hunger cues, leading to decreased appetite. Improved Blood Sugar Control: Better blood sugar management may indirectly contribute to weight loss. On average, people with diabetes taking metformin experience weight loss ranging from 4 to 7 pounds per year. However, individual responses can vary. Can Non-Diabetic Individuals Take Metformin for Weight Loss? Yes, metformin can be used for weight loss even if you don’t have type 2 diabetes. It is very unlikely cause hypoglycaemia in diabetics if used alone or with SGLT2 medications. Hypoglycaemia is a serious condition which can be fatal if not treated quickly. While we are in the middle of the video, it is essential to consult with a healthcare provider before starting any medication, including metformin, for weight management. SGLT2 inhibitors, also known as “gliflozins” or “flozins,” are a group of medications initially developed to manage type 2 diabetes. Their primary function is to lower blood glucose levels by increasing the excretion of glucose in the urine. However, their benefits extend far beyond glycemic control. https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-reduce-risk-serious-heart-problems-specifically-adults-obesity-or Time 8.15pm-3-Jun-14

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