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GLP-1 is secreted by intestinal cells in response to glucose ingestion and acts on the vagus nerve and hypothalamus to induce satiety. Subscribe to Nourishable at https://www.youtube.com/c/Nourishable This video is part 6 of the Neurobiology of Food Intake module within a lecture series on the nutrition science of macronutrients. Neurobiology of Food Intake Lecture playlist: https://youtube.com/playlist?list=PLK6oS2Cd-6PE_gAHJP2eQaP01IrvL7OQJ Macronutrients Lecture playlist: https://youtube.com/playlist?list=PLK6oS2Cd-6PGI0ALaBRBb10s51Z0NEmvw Follow Nourishable on twitter, facebook and instagram to stay up to date on all things nutrition. https://twitter.com/nourishable fb.me/nourishable.tv https://www.instagram.com/nourishable/ Lecture Development, Hosting & Post-Production by Lara Hyde, PhD http://www.nourishable.tv Video Production by Robbie Hyde https://www.youtube.com/user/chedderchowder Opening Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/ The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only. References Klockars, A. et al. Hypothalamic Integration of the Endocrine Signaling Related to Food Intake. Curr. Topics Behav. Neurosci. (2019) 43:239-270 Images Figures created with BioRender Glucagon-like peptide 1, or GLP-1, is a hormone secrets by the L cells in the intestine in response to glucose ingestion in proportion to consumed calories. GLP-1 stimulates insulin secretion from the pancreas to prepare the body for high blood glucose levels - this makes it an incretin because it increases insulin. Further, GLP-1 inhibits glucagon. GLP-1 binds to chemoreceptors on the vagus nerve to activate the vagus to send afferent signals to stimulate the nucleus tractus solitarius in the hindbrain to stimulate satiety. GLP slows gastric emptying which keeps the GI tract stretched and distended for longer - this activates the stretch-sensitive mechanoreceptors on the vagus to additionally stimulate the NTS. GLP-1 crosses the blood-brain-barrier of the hypothalamus to activate the POMC neurons in the arcuate nucleus. POMC neuron stimulation causes release of the neurotransmitter alpha MSH which stimulates the paraventricular hypothalamus to induce satiety. GLP-1 also inhibits the orexigenic AgRP neurons. GLP-1 is an anorexigenic, satiety-inducing hormone.

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What can weight-loss drug users do to combat “Ozempic face,” the rapid weight loss in the face that leaves a distorted appearance, and other side effects of muscle loss? New subscribers to our e-newsletter always receive a free gift. Get yours here: https://nutritionfacts.org/subscribe/. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/how-to-control-the-side-effects-including-ozempic-face-of-glp-1-drugs and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/how-to-control-the-side-effects-including-ozempic-face-of-glp-1-drugs. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/ https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Books: https://nutritionfacts.org/books • Shop: https://drgreger.org • Facebook: https://www.facebook.com/NutritionFacts.org • Twitter: https://twitter.com/nutrition_facts • Instagram: https://www.instagram.com/nutrition_facts_org