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Obesity, a driver of inflammation, is prevalent in patients with HFpEF. Ileana Pina asks Ambarish Pandey about GLP-1 inhibitors and SGLT2 inhibitors in HFpEF. Are these drugs anti-inflammatory? https://www.medscape.com/viewarticle/993980?src=soc_yt -TRANSCRIPT- Ileana L. Piña, MD, MPH: Hello, everyone. I'm Ileana Piña, professor of medicine at Jefferson University Hospital in Philadelphia. I'm the chief of quality. This is my blog. We have been hearing a lot of conversation about obesity. It's coming out of our endocrine division and our weight management division. And the patients are asking for things like bariatric surgery and maybe a holistic program of weight loss. A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. We see more younger folks with obesity in our HFpEF clinic coming in with symptoms of shortness of breath and fluid buildup. Our understanding of HFpEF has evolved quite a bit over the past two or three decades. Initially, it was thought to be a disease of largely impaired myocardial relaxation. And then Walter Paulus was one of the pioneers who proposed the concept of inflammation leading to HFpEF, and obesity being one of the important drivers of the inflammation that leads to the development of HFpEF. Now our understanding of HFpEF has evolved to it being a multisystem disorder that leads to dysfunction in different organ systems. One of the cardinal features that drives this dysfunction is upregulation of inflammatory pathways, increased inflammatory burden — and a lot of that is driven by obesity. Obesity is one of the most important modifiable risk factors for HFpEF. Piña: It is so common. In my clinic the other day, probably 3 out of 4 patients were obese. Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. And if you look at the data from the STEP trials that were done, looking at weight loss effects of semaglutide, a commonly used GLP-1 inhibitor, there was a good 30%-40% reduction in CRP levels, and that suggests that there is a significant anti-inflammatory effect. Now, whether it's a direct effect on anti-inflammatory pathways or is related to weight loss is a matter of debate. Piña: Are you using GLP-1 inhibitors in your HFpEF clinic? And what trials can we look forward to seeing concerning the use of these agents? https://www.medscape.com/viewarticle/993980?src=soc_yt

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Complete Keto is a revolutionary weight loss supplement that promises to help users achieve their fitness goals by following a ketogenic diet. Developed by a team of experts, this product claims to enhance metabolism, suppress appetite, and improve energy levels. Since its appearance on the hit TV show Shark Tank, Complete Keto has gained significant attention and popularity. In this comprehensive review, we will take a closer look at Complete Keto, its ingredients, benefits, and potential side effects.

Ingredients

Complete Keto is formulated with natural ingredients that are known to support weight loss. One of the key components of this supplement is beta-hydroxybutyrate (BHB), which is a ketone that helps the body enter a state of ketosis. Other ingredients include green tea extract, Garcinia Cambogia, and caffeine, all of which are believed to aid in fat burning and boosting metabolism.

Green tea extract is rich in antioxidants and can help to improve overall health. Garcinia Cambogia is a tropical fruit that contains hydroxycitric acid (HCA), which may aid in weight loss by suppressing appetite and preventing the formation of fat cells. Caffeine is a natural stimulant that can increase energy levels and improve focus, making it easier to stick to a diet and exercise routine.

Benefits

There are several potential benefits to using Complete Keto as part of a ketogenic diet. One of the main advantages is its ability to help the body enter a state of ketosis more quickly, which can lead to faster weight loss results. By increasing metabolism and suppressing appetite, this supplement may also help to control cravings and reduce calorie intake.

Complete Keto is also said to provide a boost of energy, making it easier to stay active and motivated throughout the day. This can be especially beneficial for those who struggle with fatigue while following a low-carb diet. Additionally, the natural ingredients in this product may have other health benefits, such as improving digestion and supporting overall well-being.

Side Effects

While Complete Keto is generally considered safe for most users, there are some potential side effects to be aware of. Some people may experience digestive issues such as nausea, constipation, or diarrhea when first starting this supplement. These symptoms are usually mild and should subside as the body adjusts to the ingredients.

It is important to consult with a healthcare provider before taking Complete Keto, especially if you have any underlying health conditions or are taking medication. Pregnant or breastfeeding women should also avoid using this product. As with any weight loss supplement, it is essential to follow the recommended dosage and not exceed the daily limit to avoid adverse effects.

Results

Many users of Complete Keto claim to have seen positive results after incorporating this supplement into their ketogenic diet. Some report significant weight loss, increased energy levels, and improved mental clarity. However, individual results may vary, and it is essential to combine this product with a healthy diet and regular exercise for the best outcomes.

It is important to remember that no weight loss supplement can guarantee results, and consistency is key when trying to achieve fitness goals. While Complete Keto may help to support your weight loss journey, it is still essential to make lifestyle changes that promote overall health and well-being. With dedication and determination, you may be able to reach your desired results with the help of this product.

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Overall, Complete Keto appears to be a promising supplement for those looking to enhance their ketogenic diet and achieve their weight loss goals. With its natural ingredients, potential benefits, and reported results, it is worth considering for individuals who are committed to a healthy lifestyle. As with any new supplement, it is recommended to consult with a healthcare provider before starting Complete Keto to ensure it is suitable for your individual needs.

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Kelly Clarkson has revealed that her weight loss is a result of prescription medication, which aids her body in breaking down sugar. Clarkson and Whoopi Goldberg discussed their weight loss journey, revealing that they both lost weight due to their thyroid problems. Clarkson clarified that she is not on Ozempic, which is FDA-approved for people with type 2 diabetes. She also mentioned that her new home in New York City has helped her get in shape, and her diet includes a healthy mix of protein.

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Welcome to the world of Life Keto Gummies, where you can embark on a journey towards a healthier and happier life through the power of ketosis. If you’ve been struggling to achieve your weight loss goals or improve your overall health, then these gummies may be the answer you’ve been searching for. By harnessing the natural benefits of ketosis, Life Keto Gummies can help you burn fat more efficiently, boost your energy levels, and enhance your mental clarity.

The Science Behind Ketosis

Before we delve into the wonderful benefits of Life Keto Gummies, it’s essential to understand the science behind ketosis. Ketosis is a metabolic state in which your body burns fat for energy instead of glucose. This process is triggered by a low-carbohydrate diet, forcing your body to convert stored fat into ketones for fuel. By entering ketosis, you can experience rapid weight loss, improved cognitive function, and increased energy levels.

Life Keto Gummies are specially formulated to help you reach and maintain a state of ketosis more easily. Each gummy is packed with exogenous ketones, which can jumpstart the ketosis process in your body. By consuming these gummies regularly, you can enhance the effects of a ketogenic diet and enjoy all the benefits that come with it.

The Benefits of Life Keto Gummies

1. Weight Loss: One of the primary benefits of Life Keto Gummies is their ability to promote weight loss. By supporting ketosis, these gummies can help you burn fat more efficiently, leading to a slimmer and healthier body.

2. Increased Energy Levels: Many people experience a boost in energy levels when they enter ketosis. By incorporating Life Keto Gummies into your daily routine, you can enjoy sustained energy throughout the day without the crashes associated with high-carb diets.

3. Mental Clarity: Ketosis has been linked to improved cognitive function and mental clarity. With Life Keto Gummies, you can experience sharper focus, enhanced concentration, and better overall brain health.

How to Incorporate Life Keto Gummies Into Your Routine

It’s easy to add Life Keto Gummies to your daily wellness routine. Simply take the recommended dosage each day, either on an empty stomach or with a meal. For best results, pair these gummies with a ketogenic diet rich in healthy fats, moderate protein, and low carbohydrates. You’ll soon start to notice the positive effects of ketosis on your body and mind.

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Remember to stay hydrated, get regular exercise, and prioritize quality sleep to optimize the benefits of Life Keto Gummies. Consistency is key, so make sure to take your gummies daily to experience the full effects of ketosis.

FAQ About Life Keto Gummies

1. Are there any side effects of taking Life Keto Gummies?

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Life Keto Gummies are generally well-tolerated, but some people may experience mild digestive issues when they first start taking them. These symptoms typically subside as your body adjusts to ketosis. If you have any concerns, consult with your healthcare provider before adding these gummies to your routine.

2. How long does it take to see results with Life Keto Gummies?

Results may vary from person to person, but many individuals notice improvements in their energy levels and weight within a few weeks of starting a ketogenic diet with Life Keto Gummies. Consistent use is essential for achieving long-term benefits.

3. Can I take Life Keto Gummies if I’m not following a ketogenic diet?

While a ketogenic diet can maximize the benefits of Life Keto Gummies, you can still experience some advantages even if you’re not strictly following the diet. These gummies can help support fat burning and energy levels, regardless of your current eating habits.

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The key to a faster metabolism isn't just weightlifting.....its is having protein for breakfast! (AND not eating late a night) No processed carbs and coffee upon waking. Do it for two weeks. Thank Me later! The Holistic Nutritionist.