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Semaglutide is a medication that has been making headlines for its potential to aid in weight loss. Originally developed as a treatment for type 2 diabetes, semaglutide has shown promising results in helping people shed excess pounds. But how exactly does semaglutide work to promote weight loss? In this article, we will explore the mechanisms behind semaglutide’s weight loss effects.

Mechanism of Action

Semaglutide belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs mimic the effects of a hormone called GLP-1, which is released in the gut after meals. GLP-1 helps regulate blood sugar levels by stimulating the release of insulin and inhibiting the release of glucagon, another hormone that raises blood sugar. In addition to its effects on blood sugar, GLP-1 also plays a role in regulating appetite and food intake.

When semaglutide is injected, it binds to and activates GLP-1 receptors in the brain, particularly in areas that control appetite and energy balance. By stimulating these receptors, semaglutide can help reduce feelings of hunger and increase feelings of fullness, leading to a decrease in food intake. This mechanism may contribute to the weight loss seen in patients taking semaglutide.

Effects on Metabolism

Besides its effects on appetite regulation, semaglutide may also impact metabolism in ways that promote weight loss. GLP-1 receptors are present in various tissues throughout the body, including the pancreas, liver, and muscle. When activated by semaglutide, these receptors can influence metabolism by increasing insulin sensitivity, improving glucose uptake by cells, and promoting the breakdown of stored fat for energy.

Furthermore, semaglutide has been shown to reduce liver fat content and improve markers of cardiovascular health in patients with diabetes. These metabolic effects may contribute to the weight loss observed in clinical trials of semaglutide, making it a promising option for individuals struggling with obesity.

Clinical Evidence

The efficacy of semaglutide for weight loss has been demonstrated in several clinical trials. In a large study involving over 1,900 participants with obesity or overweight, semaglutide was found to significantly reduce body weight compared to placebo. The average weight loss ranged from 10% to 15% of total body weight, with some participants losing even more.

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Moreover, patients treated with semaglutide experienced improvements in other health parameters, such as blood pressure, cholesterol levels, and glycemic control. These findings highlight the potential benefits of semaglutide beyond just weight loss, making it a promising therapeutic option for individuals with obesity and related comorbidities.

Considerations and Side Effects

While semaglutide shows promise as a weight loss medication, it is important to consider potential side effects and contraindications. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, which may improve over time as the body adjusts to the medication. In rare cases, more serious side effects such as pancreatitis or thyroid tumors may occur.

Patients considering semaglutide for weight loss should consult with their healthcare provider to discuss the potential risks and benefits. Individuals with a history of pancreatitis, thyroid disease, or other significant medical conditions may not be suitable candidates for treatment with semaglutide. It is crucial to follow a comprehensive weight management plan that includes diet, exercise, and behavioral changes in conjunction with semaglutide therapy.

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في هذا الفيديو ، يتحدث بروفيسور دكتور أوكان باكنر عضو هيئة تدريس أمراض الغدد الصماء والتمثيل الغذائي بكلية الطب بجامعة باشكنت عن العلاج بواسطة GLP-1. #لنتعرف على مرض السكري

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#FatBurnerCoffee#HowToFatBurn ☕Fat Burner Coffee☕ || How To Lose Belly Fat in Just 5 Days || 😍No Strict Diet No Workout 😍 || geeta DISCLAIMER: The information provided on this channel and its videos is for general purposes only and should Not be considered as professional advice. We are not a licensed professionals or a medical practitioner so always consult with your professional consultants or doctor in case you need. This video is only for General Information Purpose and based on our own Experience. Any information provided in this video should not be considered as a substitute for prescription suggested by a local beauty, diet and health care professionals. Viewers are subjected to use these information on their own risk.This channel does not take any4 responsibility for any harm, side-effects, illness or any health or skin care problems caused due to the use of our content or anything related to this video. 🌸🌼💮 Thanks for watching💮🌼

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If interesting in learning how to lose belly fat fast, make sure to check out our Weight Loss Course: http://thehealthnerds.com/the-science-of-fast-weight-loss-course Fast forward to today and how to lose belly fat fast is still one of the more commonly searched health and fitness topics of all time. That’s why today I’m going to show you exactly how to lose that stubborn stomach fat and start carving that sexy stomach. And it’s all backed by science. There are 5 main causes to a pesky belly bulge. #1. Overeating Kind of obvious, here but it needs to be said. The main culprit of belly fat is consuming too many calories leading to weight gain and stomach fat. And the main way to lose the belly fat is reducing fat all across the entire body. #2. Hormone Imbalances, Specifically Cortisol High amounts of the stress hormone cortisol have been linked to higher abdominal fat distribution. Other hormonal issues have also been linked with slow weight loss and difficulty for the body to properly uptake nutrients. So it’s just as important to get your hormones in check as it is to make sure your diet is aligned. #3. Bloating Missed by a lot of health professionals, bloating certainly doesn’t help with belly fat. This is usually caused by high sodium intake, excessive carbohydrate intake, and can even be a sign of food intolerance. #4. Age The older you get, the harder the process of losing belly fat will become. You can get a flat stomach at any age, it will just take more effort when you are 50 than when you are 20. #5. Alcohol Intake Studies have shown that certain types of alcohol are directly correlated with stubborn belly fat. And if your overall goal is to lose fat, cutting down on alcohol intake is a simple solution that really works. Here’s how to lose belly fat, actually backed by science!! 1. Chow Down on fiber rich foods Studies have shown there is a direct relation between fiber intake and reduction of belly fat The type of fiber you want to focus on is viscous fiber. These are the types of fibers that bind to water and slow down the digestion process. It can be found in beans, vegetables, and whole fruits 2. Cut out the two S’s – Sugar and Salt Sugar is turned into fructose in the body which gets stored as visceral fat. There are also plenty of studies that show how sugar increases belly fat, causes cravings, and is ultimately TERRIBLE for the body. Cut it out of your diet. There’s also similar problem with salt. The high salt intake in an average diet causes stored water weight and lots of belly bloat. Reducing salt intake to between 1500mg and 2000mg per day will usually result in an immediate reduction in belly bloat. 3. Drink Green Tea or Coffee Before Workouts Studies have shown that adding in caffeine before workouts -Increases work output -Helps burn more calories -Shows a greater reduction in visceral fat The best two healthy sources for caffeine are black coffee or green tea. Drink 30 minutes before exercise for more gainz and less belly fat! 4. Add Apple Cider Vinegar into The Diet Apple cider vinegar is uniquely effective for weight loss and eliminating stomach fat. Its ability to regulate blood sugar and curb appetite is also awesome for overall health. Studies have also shown that those who consume 1 -2 tablespoons daily have a significant decrease in visceral fat than those who do not (study). You can watch our video about it here if you’d like… 5. Regulate your sleep patterns. For every hour of sleep the body gets that is fewer than 8, the chances of visceral fat increase. If you’re only getting in 6 hours a night, you’ll likely have a 22% increase in the gain of visceral fat (study). There’s a reason lack of sleep is associated with cravings, high cortisol levels, poor skin, and other health issues. Get 8 hours of high quality sleep every night. 6. Eat More of These Fats A study done by Swedish scientists showed a strange result. Those who ate lots of polyunsaturated fats lost more visceral fat, lost more weight, and gained more lean muscle than those that ate other fats (study). Polyunsaturated fats can be found in fish, nuts, and seeds Studies Used: http://www.ncbi.nlm.nih.gov/pubmed/24550191 https://sleepfoundation.org/sleep-news/sleep-linked-gains-abdominal-fat http://www.ncbi.nlm.nih.gov/pubmed/19661687 http://www.ncbi.nlm.nih.gov/pubmed/22190023 http://www.ncbi.nlm.nih.gov/pubmed/19640952 http://jn.nutrition.org/content/130/2/272S.full http://www.ncbi.nlm.nih.gov/pubmed/15614200 http://www.ncbi.nlm.nih.gov/pubmed/2912010 http://www.ncbi.nlm.nih.gov/pubmed/7408399

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Lizzo is gearing up for the release of her new album, *Love in Real Life*, and reflecting on her mental health journey leading up to it. In a recent appearance on the *On Purpose With Jay Shetty* podcast,on April 7 she talked about taking a "gap year" from music releases. "I don’t feel like I’ve fully expressed myself in the past two years as I wanted to. I’ve been holding back and keeping to myself, but I believe it was for the best, especially with how things are these days," Lizzo shared. She mentioned that her break was meant to safeguard her well being, but her choice was often misunderstood. "Sometimes it’s unnecessary, and it can lead to situations you didn’t intend to get involved in because people misinterpret your actions and run with their own narratives. When I said I was taking a gap year to protect my peace, people were confused about what that meant," she explained. The singer has already released two tracks from her upcoming album, *Still Bad* and the title track. This will be her first major release since her 2022 album, *Special*, which reached No. 2 on the Billboard 200 and featured the two weeks No. 1 single. "About Damn Time." This album comes after a harassment lawsuit was filed against her by three former dancers in August 2023, accusing Lizzo and her company, Big Grrrl Big Touring Inc., of various wrongdoings. Lizzo has denied these allegations, labeling them as "false claims" and "sensationalized stories." Sometimes, it can be unnecessary, and at other times, it can lead to situations you didn't intend to get involved in because people might misinterpret things and take them too far. I realized that when I announced I was taking a gap year to focus on my well being, people responded with confusion, asking what that really meant. Lizzo shared how public perception has impacted her, stating, "When it was out of my control and someone else could tell a story about me that wasn’t true, and people believed it, it really hurt me." She continued, "What I’ve learned about fame is that even if it reflects who I really am, it turns into a fictional narrative that becomes a character, a brand, something that no longer feels like it belongs to me." The singer stressed the importance of authenticity, saying, "Whoever Lizzo is to the world isn’t truly me. That disconnect is disheartening. The only way to address it is to keep being myself. I just need to continue being me, and eventually, people will recognize the real me." Lizzo concluded, "I’m not going to stop If anything, I’m more cautious now. I can’t allow just anyone into my life who could portray me as a villain. I’m taking control of my narrative by sharing my story from my perspective, and I appreciate the chance to do that." In her first film role, Lizzo will portray Sister Rosetta Tharpe. She also opened up about her past struggles with suicidal thoughts during a comeback concert in Los Angeles last month, sharing, “I was so heartbroken by the world and so deeply hurt that I didn’t want to live anymore, and I was so afraid of people that I didn’t want to be seen. Eventually, I overcame that fear,” she told the audience at the Wiltern Theatre. Lizzo, who is open about her body transformation and health journey, recently mentioned that she prefers to call her physical changes "weight release" rather than "weight loss." "The weight I’ve shed isn’t just physical or fat," she mentioned during a podcast, explaining, "I’ve let go of so much to reach this stage, and I believe people can see that. I don’t want to label anything as a loss,". She continued, "I’m not feeling any loss. In fact, I’ve gained a lot." She shared the positive outcomes of losing weight. "I’ve found a sense of self," she stated on Jay Shetty's On Purpose podcast. "I’ve adopted a lifestyle that I truly enjoy, and I feel like I can sustain it. I’ve also gained a new understanding of nutrition and the science behind cardio and weight training". Despite Lizzo highlighting the renewal she feels from her fitness journey, she acknowledged that many might not grasp the language she uses. "People may not comprehend this right now, but it’s the most body positive way to describe what I’m experiencing," she explained. "I prefer not to use any negative language." "I want to be very deliberate with my words," she added. "There are young people watching me, and they’re interpreting what I share and applying it to their own lives, just as I did when I was younger". #usentertainmentnews #singer #viralvideo #news #artist #entertainment #americanmusician #lizzo #album #newsong #weightloss #interview.