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Welcome to our discussion on GLP-1 medication in the context of their weight loss licensing. All medication comes with risk, but as this class of medication has many benefits, including aesthetics, we believe many people have lost touch with the fact that these are regulated medication. We have became aware of online communities providing medical advice for GLP-1 medication, this is highly dangerous and this should not be a primary source of information and should be discussed with your healthcare team. There is a lot to discuss and we are aware that we cannot cover everything in this episode, also, please see our references below for any further reading. If you would like to go to a particular section, please click on the time stamp below (please note this podcast was extremely hard to time stamp, so we did our best): 00:08 - Why are we discussing GLP-1 medications again? 01:54 - Online weight-loss communities are more detrimental than good 09:58 - How is medication regulated in the UK? 16:32 - Are online pharmacies helping the situation? 20:34 - GLP-1 medication does require you to adopt a healthy lifestyle 21:58 - The controversial aspects of health? 28:52 - Social media versus health care professionals 29:58 - Let’s discuss ‘Big Pharma’ 33:08 - Our final thoughts and key points Here is our podcast link: https://open.spotify.com/show/5kJoyk0uY8u1H8CmgNDWzo?si=JF4_mY8oSES520KcOaHwhA Sign up to our newsletter: https://mailchi.mp/c15c44eee6a0/thechemistcouplepodcast As always, this podcast is for informational purposes only and should not be used in substitute to seeing a healthcare professional. Any questions, please reach out to us and thanks for listening! Here is a list of the sources that we used to make this podcast: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 https://www.nejm.org/doi/full/10.1056/NEJMoa1411892 https://www.nejm.org/doi/10.1056/NEJMoa2032183?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Rang & Dale’s Pharmacology 10th edition - general pharmacological overview

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Semaglutide is a medication that has been gaining attention for its potential in aiding weight loss. Originally developed for the treatment of type 2 diabetes, semaglutide has shown promising results in helping individuals with obesity shed unwanted pounds. But how exactly does semaglutide work for weight loss? In this article, we will delve into the mechanisms and benefits of semaglutide in promoting weight loss.

Mechanisms of Action

Semaglutide belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These drugs mimic the action of a naturally occurring hormone in the body called GLP-1. GLP-1 helps regulate blood sugar levels by stimulating the release of insulin and inhibiting the release of glucagon. In addition to its effects on blood sugar, GLP-1 also plays a role in appetite regulation and satiety.

When semaglutide is injected, it binds to GLP-1 receptors in the body and activates them. This leads to increased insulin secretion, decreased glucagon secretion, and slowed gastric emptying. These effects help lower blood sugar levels, but they also have the added benefit of promoting weight loss. By slowing down gastric emptying, semaglutide can make individuals feel fuller for longer periods, reducing overall food intake.

Furthermore, semaglutide may also act on the brain to decrease hunger and food cravings. Studies have shown that GLP-1 receptors are present in areas of the brain that control appetite and reward, suggesting that semaglutide may have direct effects on the central nervous system to reduce food intake and promote weight loss.

Benefits of Semaglutide for Weight Loss

One of the main benefits of semaglutide for weight loss is its effectiveness. Clinical trials have shown that individuals taking semaglutide in combination with lifestyle modifications can achieve significant weight loss compared to those taking a placebo. In fact, some studies have reported weight loss of up to 15% of initial body weight in participants treated with semaglutide.

In addition to its weight loss benefits, semaglutide may also improve other metabolic parameters. Studies have shown that semaglutide can lead to reductions in blood pressure, cholesterol levels, and markers of inflammation in individuals with obesity. These improvements in metabolic health may help reduce the risk of developing obesity-related complications such as heart disease and diabetes.

Potential Side Effects

While semaglutide has shown promise in aiding weight loss, it is not without potential side effects. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These gastrointestinal symptoms typically improve over time as the body adjusts to the medication. In some cases, semaglutide may also cause hypoglycemia (low blood sugar), especially when taken in combination with other diabetes medications.

More serious side effects of semaglutide may include pancreatitis, gallbladder disease, and thyroid tumors. It is important to discuss the potential risks and benefits of semaglutide with a healthcare provider before starting treatment. Individuals with a history of pancreatitis, gallbladder disease, or thyroid cancer may not be suitable candidates for treatment with semaglutide.

Long-Term Success and Considerations

For long-term success with semaglutide for weight loss, it is important to adopt healthy lifestyle habits such as a balanced diet and regular exercise. Semaglutide should be used as part of a comprehensive weight management plan that includes behavioral counseling and support. It is not a magic bullet for weight loss, but rather a tool that can aid individuals in achieving their weight loss goals.

It is also important to note that semaglutide is a prescription medication and should only be used under the supervision of a healthcare provider. Regular monitoring of blood sugar levels, weight, and potential side effects is essential while taking semaglutide. If weight loss goals are not being met or if side effects become bothersome, it is important to discuss these concerns with a healthcare provider to determine the best course of action.

In conclusion, semaglutide is a promising medication for weight loss that works by mimicking the effects of a hormone called GLP-1 in the body. By increasing insulin secretion, decreasing glucagon secretion, and slowing gastric emptying, semaglutide can help individuals feel fuller and eat less, leading to significant weight loss. While semaglutide may have potential side effects, its benefits in promoting weight loss and improving metabolic health make it a valuable option for individuals struggling with obesity. With proper guidance and monitoring, semaglutide can be a useful tool in achieving long-term weight loss success.

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