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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Sign up for updates about each new episode: https://info.insidetracker.com/longevitybydesign View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1 Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity. The Impact of GLP-1 on Fertility Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences. “If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.” We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

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UNLEASH with Bipasha Basu ► http://bit.ly/BipashaWorkout Subscribe to Stay Fit ► http://bit.ly/GH24by7 Bipasha Basu does a full body advanced workout that will keep you fit and healthy and keep your body toned. Loving yourself and pampering yourself has never been an easy task, the dusky diva of Bollywood none other than Bipasha Basu, has made this very simple by introducing us to a repertoire of a fitness regime, called ""Fit & Fabulous You"". In this video Bipasha tells us of how to do a rigorous 30 mins workout and burn the fat out of you and at the same time increase the metabolism of your body. The routine helps strengthen the bones and improves muscle coordination. Like, Comment and Share with your friends and family. #bipashabasuworkout #bipashabasu #fitnessvideo #cardioworkout #fatburningworkout #bodytoning #aerobicsworkout #weightloss #aerobics #fatburning #weightloss #cardio #workout #workoutmotivation #workoutathome #gymmotivation #gymlover Connect with us on :- Facebook - https://www.facebook.com/GoodHealth24by7 Twitter - https://twitter.com/goodhealth24by7 Instagram - https://www.instagram.com/goodhealth24by7

Kelly Clarkson Reveals Her Weight Loss Journey

Emily’s splendid weight loss transformation has seen her being featured in most tabloids as one of the latest housewives on the Real Housewives franchise. Emily’s journey to fitness as shown in the show has been followed by fans because of her struggle to make it come true. Nevertheless, there are various aspects concerning Simpson’s weight loss shown on TV. The following article will provide a more detailed account of Emily Simpson’s Real Housewives weight loss reality.

Emily’s Weight Loss Journey Begins

Before she joined Real Housewives of Orange County, Emily Simpson had struggled with her weight for years. As an attorney who is always busy and a mother to three young children, maintaining good health was not easy for Emily. She often turned to food for comfort and struggled to find the time to exercise regularly.

However, despite being so active, Emily knew that something had to change if she wanted her body to be generally healthy. She made up her mind on living healthier and also got associated with a team of professionals who helped through her weight loss journey.

Having family and friends’ support, Emily started exercising regularly into her daily routine and made major changes in her diet. She mainly ate whole food rich in nutrients while remaining moderate during meal times together with doing regular cardiovascular exercises. Eventually, this was accompanied by both physical and emotional improvement due to hard work done by Emily.

How Mental Health Matters In Her Weight Loss Efforts

Although she underwent visible changes physically, Emily’s mental health played a big role throughout his journey towards shedding off some fats from his body system. For example, all through this period of transformation there were moments when he openly talked about his battles with self-esteem issues concerning body shape.

Furthermore, it is possible today after watching this series of real housewives that makes one feel confident about oneself while addressing these crucial matters like self-acceptance using their own personal experiences as examples. However, she opened up about anxieties regarding her body and used this reality show as a platform for these discussions regarding self-esteem.

Therefore, by focusing on her mental health and engaging in self-care, Emily has been able to maintain a positive outlook on her weight loss journey and achieve all of her goals. She also continues to motivate many others who have huge bodies so that they may appreciate themselves without minding their sizes.

Overcoming Obstacles and Defeats

Emily has faced numerous challenges and setbacks like other people who are trying to shed off some weight. Balancing between career, family life and fitness goals has been among these challenges which she has openly shared with the public. There have also been times where Emily felt defeated or overwhelmed, nevertheless she remained determined and resiliently fought for her well-being.

In addition, Emily has opened up about yo-yo dieting experiences she underwent as well as how important it is for one to adopt a sustainable method towards losing weight. Listening to your body needs while ignoring the scales figures was a lesson Emily learned in her life due to her repeated experiences with diets of yoyo nature. Finally, through trial and error, she found what works best for herself thereby developing an effective routine that can be fun at the same time.

However hard it may seem at first instance, Simpson’s passion towards good health never ceases. Henceforth she will work out even harder to influence other people positively to do better in their lives. This is clearly shown by 1Z0-980 Guide Exam Dumps Oracle Sales Cloud 2017 Implementation Essentials some of his actions such as continuous self-determination that reminds everyone of the possibility of transforming via effort plus support.

Others Empowering Themselves through the Story of Emily

The weight loss journey of Emily Simpson is not all about transition from one physical state to another – it also entails self-empowerment and self-actualization. The Real Housewives of Orange County’s adventure of Emily on the show has been a source of motivation for many viewers towards improving their health.

Sharing both her ups and downs throughout her weight loss journey, Emily has achieved genuineness and vulnerability that appeals to people around the world. She can be admired by those who hope to have better lives through good health by being an inspiration that shows it is never too late to change and take care of oneself.

As she keeps narrating her story and advocating for body positivity, some important talks regarding beauty standards, self-embracing, mental wellness and emotional well-being are emerging between Emily. This is one more reason why everyone needs to know that reformation starts within us as individuals; hence each one has the potentiality to bring about positive changes in his/her life

Emily Simpson’s weight loss reality goes beyond what is seen on television. Her journey stands out because it demonstrates how far determination, love for oneself, resilience can carry someone. By telling her story honestly and openly about herself, Emily has caused lots of individuals into choosing a path that would lead them towards gaining control over their health and appreciating their unique beauty. It does not matter whether she is confronting challenges head on or celebrating victories or empowering others; what matters most is that anyone willing to transform through hard work while believing in themselves can do this just like Emily’s own story illustrates.

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The Weight Loss Project Day 3

From Trump's mastery of attention to fashion's new masculinity, exploring January's most thought-provoking cultural signals In this episode, Igor and Johannes kick off 2025 with a new monthly format exploring the media and cultural phenomena that captured their attention. They dive into two key topics that set the tone for the year ahead: First, they examine Chris Hayes and Ezra Klein's conversation about the attention economy and its implications for politics, drawing parallels between U.S. and German political landscapes. The discussion reveals how attention, rather than traditional metrics like fundraising, increasingly shapes political outcomes and cultural discourse. Second, they explore the role of curiosity and informed naivety through the lens of ERL, a Venice Beach fashion brand that offers an alternative approach to masculine aesthetics. This leads to broader reflections on meta-modernism and ways to engage with complex cultural topics beyond pure cynicism or oversimplification. The episode concludes with updates on GLP-1 medications, exploring new research about natural alternatives and emerging evidence about their effects on addiction, bringing fresh perspective to themes from previous seasons. Chapters: 00:00 - Introduction & New Format 02:14 - Attention Economy in Politics 14:45 - ERL & Meta-modernist Approaches 29:22 - GLP-1 Updates & Natural Alternatives 44:51 - Closing Thoughts Links: - Podcast episode with Ezra Klein and Chris Hayes: https://www.nytimes.com/2025/01/17/opinion/ezra-klein-podcast-chris-hayes.html - Erl Website: https://erl.store/ - Systems Magazine interview with Erl founder Eli Russel Linnetz: https://system-magazine.com/issues/issue-18/erl-eli-russell-linnetz-interview-andrew-bolton - Dr. Michael Greger on restoring our natural GLP-1 satiety circuit with fiber (video): https://nutritionfacts.org/video/a-plant-based-diet-for-weight-loss-boosting-glp-1-and-restoring-our-natural-satiety-circuit/ - OZEMPIC: Risks, Benefits, and Natural Alternatives to GLP-1 Weight-Loss Drugs (book) by Michael Greger: https://nutritionfacts.org/book/ozempic/ - Weight Loss Drugs for Curing Addiction? Podcast episode with Chris Hayes and Nicholas Reville: https://podcasts.apple.com/us/podcast/weight-loss-drugs-for-curing-addiction-with-nicholas/id1382983397?i=1000683904777 This episode marks a shift to a new monthly format where Igor and Johannes will reflect on the articles, conversations, and cultural phenomena that shaped their thinking. The discussion weaves together themes of attention economics, cultural aesthetics, and health trends while maintaining the show's focus on helping listeners update their mental models of how the world is changing. You can also listen to this episode on Apple, Spotify or wherever you get your podcasts. Follow the Rabbit on Spotify at https://podcasters.spotify.com/pod/show/follow-the-rabbit Follow the Rabbit on Apple at https://podcasts.apple.com/au/podcast/follow-the-rabbit/id1763655913 Follow the Rabbit on YouTube at https://www.youtube.com/channel/UCXKCXmFazhd1SZxoawCku0w Follow the Rabbit is a Known Unknowns production Known Unknowns on YouTube at https://www.youtube.com/@knownunknowns-xyz Known Unknowns on Instagram at https://www.instagram.com/knownunknowns.xyz/ 📧 Write to us at [email protected] Follow the Rabbit is hosted by Igor Schwarzmann & Johannes Kleske Find out more about Igor Schwarzmann at https://igorschwarzmann.com Find out moire about Johannes Kleske at https://johanneskleske.com

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Starting my Zepbound (tirzepatide) journey! After years of workouts, healthy eating, and even fibroid surgery, I’m giving GLP-1 injections a shot (literally). Excited, and a little nervous, to see where this takes me. Have you tried GLP-1 medications for weight loss? How was your experience? Drop your stories or questions in the comments! Video Chapters: 0:00 - Why I'm starting Zepbound (Tirzepatide) 0:13 - Current Weight + Body Scan 1:00 - Goal Weight 1:30- Injection Prep 3:07 - Zepbound (Tirzepatide) Injection (ouch!) 4:20 - Healthy Meal Planning Related Videos 🎥 https://youtu.be/2Jc4KHV-OeI 🎥 https://youtu.be/dOLEcei-zO0 🎥 https://youtu.be/h0kh-On8qnk 🎥 https://youtu.be/ZprgidNvL6M 🎥 ç Connect with Me: 💻 TikTok: https://www.tiktok.com/@sixfigureea 💻 TikTok: https://www.tiktok.com/@funmidosunmu 📸 Instagram: https://www.instagram.com/sixfigureea 📸 Instagram: https://www.instagram.com/fumsterrr 🖇️ LinkedIn: https://www.linkedin.com/in/funmi-dosunmu/ 📧 Inquiries: [email protected] Links & Resources 📖Executive Assistance 101: https://www.sixfigureea.com/enrollment 📄 Free Resume Template: https://www.sixfigureea.com/linkinbio 📚 Free Webinar: Navigate Your First 30 Days as an EA: https://www.sixfigureea.com/registration-page 💼 Coaching Calls: Book a 1:1 session with me to level up your career: https://www.sixfigureea.com/coachingcall 🗂️ EA Templates: Get access to my digital tools and templates: https://www.sixfigureea.com/linkinbio #Zepbound #Tirzepatide #WeightLossJourney #FitnessGoals #GLP1

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