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Dr. Dominic ("Dom") D'Agostino is an expert on a wide range of topics related to metabolic health, ketosis, and ketogenic diets. As one of the world's foremost experts on the ketogenic diet, Dom has personally practiced some variation of ketogenic diet for over a decade, bringing a substantial amount of practical experience along with his anecdotes from human and animal research. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/dominic-dagostino-2?utm_source=youtube&utm_medium=youtube&utm_campaign=dagostino-2_interview Dr. Dominic D'Agostino on Twitter: https://twitter.com/DominicDAgosti2 Dr. Dominic D'Agostino on Instagram: https://www.instagram.com/dominic.dagostino.kt https://www.ketonutrition.org https://metabolichealthsummit.com/ PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=dagostino-2_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/074-dr-dominic-dagostino-on-developing-a-well/id818198322?i=1000559009539 Spotify: https://open.spotify.com/episode/04zS9jd6KZcKs7paryjrXy?si=9f98821bf9ef4034 Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi Chapters: 00:00:00 - In this episode 00:01:15 - What is "keto" 00:04:59- Types of ketogenic diets 00:11:44 - Lifestyle Ketogenic Diet 00:22:54 - Biomarkers and hyperlipidemia 00:25:59 - Micronutrients and supplementation 00:29:58 - Exogenous Ketones 00:52:07 - What's the optimal level of circulating ketones? 01:09:51 - Exercise performance and anti-catabolic effects 01:30:57 - Brain and memory 01:38:59 - Intermittent Fasting 01:48:04 - Neurodegenerative diseases 01:54:27 - Migraines 02:00:39 - Autoimmune disease 02:02:37 - Cancer 02:18:26 - Carnivore diet 02:24:45 - Dom's lifestyle habits 02:28:10 - Measuring ketones (see also 52:07) 02:40:10 - Learn more about Dom Premium subscribers of FoundMyFitness get access to a Google Presentation for the graphics in videos, earlier access, a two-times-per-month science news digest and commentary, and some kind of live online event usually every month. Learn more at: https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=dagostino-2_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d #ketogenic #Diet #Metabolism
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Semaglutide, a drug commonly used to treat type 2 diabetes, has been making headlines for its surprising side effect – weight loss. This unexpected benefit has sparked interest among researchers and health professionals alike, leading to a deeper investigation into the science behind why semaglutide causes weight loss. What is it about this medication that helps patients shed pounds, and how can we use this knowledge to develop more effective weight loss treatments? Let’s delve into the science behind semaglutide and unravel why it is so effective at promoting weight loss.
The Role of GLP-1 Receptors in Weight Regulation
One of the key mechanisms through which semaglutide promotes weight loss is by activating GLP-1 receptors in the body. GLP-1, or glucagon-like peptide-1, is a hormone produced in the intestines in response to food intake. It plays a crucial role in regulating blood sugar levels and appetite, making it an important player in weight management. When semaglutide binds to GLP-1 receptors, it triggers a cascade of events that result in increased feelings of fullness, reduced food intake, and ultimately, weight loss.
Furthermore, the activation of GLP-1 receptors by semaglutide also leads to a slowing down of gastric emptying, which means that food stays in the stomach for longer periods of time. This delay in digestion not only helps to control blood sugar levels but also prolongs feelings of satiety and reduces overall caloric intake. By targeting these receptors, semaglutide is able to address both the physiological and behavioral aspects of weight management, making it a powerful tool for combating obesity.
Additionally, the activation of GLP-1 receptors by semaglutide has been shown to increase energy expenditure in the body. This means that patients taking the medication burn more calories at rest, helping them to achieve a negative energy balance that is essential for weight loss. By boosting metabolism and promoting fat oxidation, semaglutide helps to shift the body’s energy balance in favor of weight reduction, making it easier for patients to achieve their weight loss goals.
The Impact of Semaglutide on Food Cravings
Another important factor in the weight loss effects of semaglutide is its ability to reduce cravings and food-seeking behavior. Studies have shown that the medication can modulate the brain’s reward pathways, specifically those involving dopamine, which is a neurotransmitter associated with pleasure and motivation. By dampening the brain’s response to food cues and reducing the rewarding effects of eating, semaglutide helps patients to make healthier food choices and resist temptations that can sabotage their weight loss efforts.
Furthermore, semaglutide has been found to decrease the hedonic value of food, meaning that it reduces the pleasure derived from eating high-calorie, palatable foods. This can help patients break free from unhealthy eating patterns and develop a more positive relationship with food. By altering the brain’s perception of food and reducing the drive to eat for pleasure rather than hunger, semaglutide empowers patients to make lasting changes to their eating habits and achieve sustainable weight loss.
Overall, the impact of semaglutide on food cravings and reward pathways offers a unique approach to weight management that goes beyond traditional diet and exercise interventions. By targeting the brain circuits involved in food motivation, semaglutide helps patients overcome the psychological barriers to weight loss and establish long-term habits that support their health and well-being.
The Gut-Brain Axis and Weight Regulation
One of the key mechanisms through which semaglutide exerts its weight loss effects is by modulating the gut-brain axis, a complex communication system that connects the gut with the brain. This bidirectional pathway plays a crucial role in regulating appetite, metabolism, and energy balance, making it an important target for weight management interventions. By enhancing the signaling between the gut and the brain, semaglutide is able to fine-tune the body’s hunger and satiety signals, helping patients make better food choices and control their caloric intake.
Moreover, the gut-brain axis is also involved in regulating energy expenditure and fat storage. Semaglutide has been shown to influence the activity of brown adipose tissue, a type of fat that burns calories to generate heat. By activating brown fat and increasing thermogenesis, semaglutide helps patients burn more calories and lose weight more effectively. This metabolic shift not only promotes weight loss but also improves insulin sensitivity and metabolic health, offering additional benefits beyond just shedding pounds.
Overall, the modulation of the gut-brain axis by semaglutide represents a novel approach to weight management that leverages the intricate interplay between the digestive system and the central nervous system. By harnessing the power of this communication network, semaglutide offers a comprehensive solution to weight loss that addresses both the physiological and psychological factors that contribute to obesity.
The Role of Inflammation in Obesity and Metabolic Dysfunction
In recent years, researchers have uncovered a link between inflammation and obesity, suggesting that chronic low-grade inflammation plays a key role in the development of metabolic dysfunction and weight gain. Semaglutide has been shown to have anti-inflammatory effects in the body, which may contribute to its weight loss benefits. By reducing systemic inflammation and improving metabolic health, semaglutide helps patients achieve sustainable weight loss and reduce their risk of obesity-related complications.
Furthermore, the anti-inflammatory properties of semaglutide extend beyond weight loss and may have broader implications for overall health. Chronic inflammation is associated with a host of chronic diseases, including heart disease, diabetes, and certain types of cancer. By targeting inflammation at its root, semaglutide has the potential to improve not only weight management but also long-term health outcomes, making it a valuable asset in the fight against obesity and its associated comorbidities.
Overall, the ability of semaglutide to modulate inflammation and improve metabolic health represents a promising avenue for combating obesity and its related complications. By addressing the underlying inflammatory processes that contribute to weight gain, semaglutide offers a holistic approach to weight management that goes beyond calorie counting and exercise, paving the way for a new era of personalized, precision medicine in the field of obesity treatment.
Conclusion
In conclusion, the weight loss effects of semaglutide are multifaceted and involve a complex interplay of physiological, neurological, and immunological pathways. By targeting GLP-1 receptors, modulating food cravings, enhancing the gut-brain axis, and reducing inflammation, semaglutide offers a comprehensive solution to weight management that addresses the root causes of obesity. As our understanding of the science behind semaglutide continues to grow, we can unlock new possibilities for personalized, precision medicine approaches to weight loss that take into account the unique biology of each individual. With further research and innovation, semaglutide has the potential to revolutionize the treatment of obesity and help millions of individuals achieve their weight loss goals.
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