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In this video we will go over the most common foods that can get you in trouble when you are trying to lose weight. It doesn't matter what diet plan you are on, if you are eating these foods you are going to struggle. If you are looking for a more comprehensive look on what lifestyle changes you can make check out this video: https://youtu.be/h1i3rT-MuTo Learn more about our practice at: www.saltzerhealth.com Thanks for watching. ** The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained in this video is for general information purposes only and does not replace a consultation with your own doctor/mental health professional ** All images and additional video segments contained in the Thumbnails and/or B-roll segments are used in strict compliance with the appropriate permissions and licenses required from https://pixabay.com and/or https://stock.adobe.com and in accordance with the YouTube Partner Program, Community guidelines & YouTube terms of service

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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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Are you a fan of the keto diet but struggle to incorporate apple cider vinegar (ACV) into your routine? ACV Keto Gummies may be the perfect solution for you! These gummies combine the benefits of ACV with the keto-friendly ingredients to help you stay on track with your diet and health goals.

Benefits of ACV Keto Gummies

ACV Keto Gummies offer a convenient and tasty way to incorporate apple cider vinegar into your daily routine. ACV has been known for its various health benefits, including weight loss, improved digestion, and balanced blood sugar levels. By combining ACV with the ketogenic diet principles, these gummies can help boost your energy, reduce cravings, and support fat burning.

One of the main benefits of ACV Keto Gummies is their portability and convenience. Instead of having to drink a shot of apple cider vinegar or mix it into your meals, you can simply pop a few gummies in your mouth wherever you are. This makes it easier to stay consistent with your ACV intake, even when you’re on the go.

In addition to the convenience factor, ACV Keto Gummies are also formulated with keto-friendly ingredients. These gummies are low in carbs and sugar, making them an ideal snack or supplement for those following a ketogenic diet. They can help support your body’s fat-burning processes while providing a delicious treat to satisfy your sweet tooth.

How ACV Keto Gummies Work

ACV Keto Gummies work by combining the benefits of apple cider vinegar with the principles of the ketogenic diet. Apple cider vinegar has been shown to help improve digestion, regulate blood sugar levels, and promote weight loss. When taken in supplement form, such as through gummies, ACV can provide these benefits in a more convenient and palatable way.

One of the key components of ACV Keto Gummies is acetic acid, which is the main active compound in apple cider vinegar. Acetic acid has been linked to various health benefits, including appetite suppression, improved metabolism, and reduced fat storage. By incorporating acetic acid into gummy form, you can experience these benefits without the harsh taste of straight apple cider vinegar.

Additionally, ACV Keto Gummies contain other ingredients that support the ketogenic diet, such as MCT oil and collagen. MCT oil is a type of fat that is quickly absorbed by the body and converted into ketones, which can help support your energy levels and mental clarity on a keto diet. Collagen is a protein that can help support healthy skin, joints, and muscles while on a low-carb, high-fat diet.

Are ACV Keto Gummies FDA Approved?

One common question that arises when considering ACV Keto Gummies is whether they are approved by the FDA. The FDA does not approve dietary supplements like ACV Keto Gummies specifically, but they do regulate them to ensure they are safe for consumption. This means that the ingredients used in ACV Keto Gummies are generally recognized as safe (GRAS) and have been tested for quality and purity.

It’s always important to do your own research and consult with a healthcare professional before adding any new supplement to your routine, including ACV Keto Gummies. While the FDA does not have specific approval for these gummies, they can still be a safe and effective way to incorporate apple cider vinegar into your diet.

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As with any supplement, it’s essential to follow the recommended dosage and not exceed it. ACV Keto Gummies are meant to be taken as a supplement to your diet, not as a replacement for whole foods. By incorporating these gummies into a balanced diet and exercise routine, you can experience the benefits of apple cider vinegar and the ketogenic diet in a convenient and delicious way.

Final Thoughts

Overall, ACV Keto Gummies can be a convenient and tasty way to incorporate apple cider vinegar into your daily routine while following a ketogenic diet. These gummies offer a portable and delicious alternative to traditional ACV supplements, making it easier to stay consistent with your health goals. While the FDA does not specifically approve these gummies, they can still be a safe and effective addition to your diet when taken as directed.

Remember to always consult with a healthcare professional before adding any new supplement to your routine, including ACV Keto Gummies. By combining the benefits of apple cider vinegar with the principles of the ketogenic diet, you can support your weight loss and overall health in a more enjoyable way. Give ACV Keto Gummies a try and see how they can help you reach your health goals!

FAQs About ACV Keto Gummies

1. Are ACV Keto Gummies safe to take every day?

Yes, ACV Keto Gummies are safe to take daily as long as you follow the recommended dosage. Be sure to consult with a healthcare professional before adding any new supplement to your routine.

2. Can ACV Keto Gummies help with weight loss?

ACV Keto Gummies may help support weight loss when combined with a healthy diet and exercise routine. The apple cider vinegar in the gummies can help boost metabolism and reduce cravings.

3. How do ACV Keto Gummies taste?

ACV Keto Gummies are generally designed to have a sweet and tangy flavor, similar to traditional gummy candies. They offer a delicious way to get your daily dose of apple cider vinegar.

4. Can I take ACV Keto Gummies if I’m not on a ketogenic diet?

Yes, you can still enjoy the benefits of ACV Keto Gummies even if you’re not following a strict ketogenic diet. The gummies can help support digestion, blood sugar levels, and weight management for anyone looking to improve their overall health.

5. Where can I buy ACV Keto Gummies?

ACV Keto Gummies are available for purchase online through various retailers. Be sure to read reviews and check the ingredients before making a purchase to ensure you’re getting a high-quality product.

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When it comes to losing weight, many people are looking for natural alternatives to help them reach their goals. Natural weight loss pills have become increasingly popular for those seeking a safe and effective way to shed unwanted pounds. These pills are made from natural ingredients that are believed to help support weight loss efforts without the potential side effects of synthetic weight loss supplements.

Natural Weight Loss Pills: What to Look For

When choosing a natural weight loss pill, it’s essential to look for products that have been scientifically researched and are known to be safe and effective. Some key ingredients to look for in natural weight loss pills include green tea extract, Garcinia Cambogia, and forskolin. These ingredients have been shown to support weight loss in various studies and are generally well-tolerated by most individuals.

Green tea extract is a popular ingredient in natural weight loss pills due to its high antioxidant content and ability to boost metabolism. Studies have shown that green tea extract can help increase fat burning and promote weight loss, making it a valuable addition to any weight loss supplement.

Garcinia Cambogia is another natural ingredient commonly found in weight loss pills. It is derived from the fruit of the Garcinia gummi-gutta tree and is believed to help suppress appetite and block the production of fat in the body. Garcinia Cambogia has been studied for its weight loss benefits and is a popular choice for those looking for a natural way to support their weight loss journey.

Benefits of Natural Weight Loss Pills

One of the main benefits of natural weight loss pills is that they are generally considered safe for most individuals to use. Unlike synthetic weight loss supplements, natural weight loss pills are made from ingredients that are found in nature and are less likely to cause harmful side effects.

In addition to being safe, natural weight loss pills also offer a range of other benefits. Many natural weight loss pills contain ingredients that can help boost metabolism, suppress appetite, and increase fat burning, making it easier for individuals to reach their weight loss goals. These pills can also provide additional benefits such as increased energy levels and improved mood, making it easier to stick to a healthy diet and exercise routine.

Another benefit of natural weight loss pills is that they are often more affordable than synthetic weight loss supplements. Since natural weight loss pills are made from ingredients that are readily available, they are generally less expensive to produce, making them a cost-effective option for those looking to support their weight loss journey without breaking the bank.

Choosing the Right Natural Weight Loss Pill for You

When choosing a natural weight loss pill, it’s essential to do your research and choose a product that is backed by scientific evidence and has positive customer reviews. Look for products that contain high-quality ingredients and have been tested for safety and efficacy to ensure you are getting a product that will help support your weight loss goals.

It’s also important to consult with your healthcare provider before starting any new weight loss supplement, especially if you have any underlying health conditions or are taking medications. Your healthcare provider can help you determine if a natural weight loss pill is a safe and appropriate option for you and can provide guidance on how to incorporate it into your weight loss plan.

By choosing a natural weight loss pill that is safe and effective and incorporating it into a healthy diet and exercise routine, you can support your weight loss efforts and reach your goals in a safe and sustainable way.

Summary: Natural Weight Loss Pills FAQ

Are natural weight loss pills safe to use?

Natural weight loss pills are generally considered safe for most individuals to use, as they are made from natural ingredients that are well-tolerated by the body. However, it’s essential to consult with your healthcare provider before starting any new weight loss supplement to ensure it is safe for you to use.

What are some common ingredients in natural weight loss pills?

Common ingredients in natural weight loss pills include green tea extract, Garcinia Cambogia, and forskolin. These ingredients have been studied for their weight loss benefits and are commonly used in natural weight loss supplements to support fat burning, boost metabolism, and suppress appetite.

How do natural weight loss pills work?

Natural weight loss pills work by utilizing ingredients that have been shown to support weight loss efforts. These ingredients can help increase metabolism, suppress appetite, and promote fat burning, making it easier for individuals to reach their weight loss goals when combined with a healthy diet and exercise routine.

Can natural weight loss pills help me lose weight?

Natural weight loss pills can help support weight loss efforts when combined with a healthy diet and exercise routine. While results may vary for each individual, natural weight loss pills can provide additional support to help you reach your weight loss goals in a safe and effective way.

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