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http://AllWeightLossNow.com Twelve-Day Grapefruit Diet How great would it be to shed a bunch of unwanted pounds in less than two weeks? Of course, that sounds like a dream-come-true, right? Well, the twelve-day grapefruit diet claims to do just that. I am wary of any diet that insists you eat only one certain food, or one food most of the time, but there are definitely some health benefits to be found in the yummy citrus fruit we call grapefruit. The grapefruit diet that has been around for a number of years is also known as the twelve day grapefruit diet because it is designed to be done for twelve days, with two days off, then resumed for twelve more days, and so on, until you lose the amount of weight you want to lose. For the most part, the twelve day grapefruit diet limits your calorie intake to a very minimal eight hundred calories per day. Can you imagine? When you only consume eight hundred calories, whether you include grapefruit or not, you are bound to lose some weight. However, the twelve day grapefruit diet does have you either eat grapefruit or drink grapefruit juice with every meal. In addition, it limits the other types of foods you can enjoy. For example, the veggies you must give up on the twelve day grapefruit diet include tomatoes, celery, cabbage, peas, cucumbers, green beans and lettuce. That being said, the twelve day grapefruit diet seems very hard to maintain. Yes, if you only have a few pounds to lose, you might want to try the grapefruit idea, but as far as using it as a regular eating plan, that seems unwise. The twelve day grapefruit diet is much too restrictive; it would be difficult to find anyone who had the stamina even folks who adore grapefruit to maintain such restrictions for long. What is good about grapefruit, though? Isnt fruit supposed to be good for us? Yes, of course it is. Grapefruit is a great source of vitamin C. It is definitely low in calories. Many folks who swear by the greatness of colon cleansing use grapefruit as part of their cleansing plan. Also, grapefruit seems to decrease the amount of insulin in the bloodstream. This is definitely great news for people with diabetes or with a diabetic tendency in their genetic makeup. In addition to vast amounts of vitamin C and insulin regulation, grapefruit may also help control cholesterol, which is a powerful tool in avoiding heart disease. There is even some ongoing research that might suggest that grapefruit helps fight cancer because of its DNA-repairing abilities. Of course, lets not forget the basics. The twelve day grapefruit diet will give you fiber, vitamin C, potassium, and folic acid, which are all good. It may not be the best idea to latch onto a particular-food diet as a long-term way to eat, so the twelve-day grapefruit diet should not be used for a lifelong nutritional plan; however, grapefruit definitely is delicious and has a lot of health benefits, so go ahead and peel yourself one or slice one in half and dig out the little triangles of lusciousness. Lets face it the grapefruit would make a great substitute for a mid morning or afternoon snack, in place of an energy drink or candy bar.

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Obesity is a global epidemic with more than a quarter of the population dealing with this metabolic syndromeWhile there are tens of thousands of solutions to suppress your weight/make you lose weight, 99% of them are band-aid solutions & do not focus on what makes you obese. Those companies &/or coaches, it is a financial model! You need to maintain your weight, you need to pay them every month to subscribe to their fad diet solutions & working schedules/plans. What causes Obesity? It is low grade chronic inflammation! So you must be wondering how inflammation in your intestines can make you gain weight? There is whole science behind & most of the biological decisions inside our body are driven by our microbiome. You may blame energy metabolism & try to create that energy deficit by eating less & burning more but energy metabolism is not about this mathematical equation. There is a web of molecular features & pathways driven by interaction between your microbiome & external environment & nutrition choices. These microbes impact/produce certain protein /hormones such as GLP-1, PYY Ghrelin & Leptin that impacts your satiety & hunger responses. While these are not the only pathways! There are multiple other interactions such as production of nitric oxide & expression of Nitric Oxide synthase that can impact your weight management & make you develop obesity However, new age medical weight loss companies have made you believe that anti-obesity drugs such as GLP-1 receptor agonists can make you lose weight. This is far away from reality -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. Myself & Sakshi discuss today what could render GLP-1 drug ineffective We at Genefitletics measures each of these gut & oral microbiome pathways to understand the changes in biology & chemistry before & during disease onset & provide interventions to bring your body back into homeostasis position Citations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793908/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021470/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833664/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268073/

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